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pentobarbital will reduce the extent or outcome of voriconazole by affecting hepatic enzyme CYP2C9/10 metabolism. Slight/Significance Unidentified.pentobarbital decreases levels of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can lessen panobinostat concentrations by ~70% and lead